Liver

Recent Findings on liver

• A study of acupuncture combined with the Jieyu Huoxue Formula investigated treatment of optic atrophy (OA) characterized in the study as the “liver depression and qi stagnation” type. The investigators sought to evaluate clinical efficacy and to measure associated changes in hemorheology and retrobulbar blood flow. In this context, the liver is used within a traditional-medicine diagnostic framework rather than as a demonstrated anatomical cause of optic-nerve injury; the provided abstract context does not report the treatment results 42114798May.

• Research on a pectic polysaccharide isolated from corn silk examined its structural characteristics and its potential protective mechanism against MASLD through regulation of the gut–liver axis. The study therefore linked intestinal processes, hepatic lipid metabolism, inflammation, and oxidative stress in the investigation of liver protection; the supplied context does not specify the experimental outcomes 42493082Jul.

• An anatomical and operative study addressed right upper abdominal cytoreduction, focusing on liver mobilization, anatomical planes, and occult spaces. Its subject is the practical relationship between the liver and surrounding abdominal structures during extensive cancer surgery, with relevance to operative exposure and the identification of surgically hidden spaces. No specific complication rate or clinical outcome is provided in the supplied publication context 42726425Sep.

• A pediatric case report described hepatic sarcoidosis presenting with hypersplenism and portal hypertension. The report emphasized that predominant hepatic disease without pulmonary or other systemic manifestations is exceptionally uncommon in children and may be diagnostically difficult when liver enzymes remain normal. The association with the spleen and portal circulation illustrates that clinically important liver disease may be present despite limited biochemical evidence and absent lung involvement 42728066Sep.

• A regulatory toxicology study evaluated harmonized classifications under the REACH framework for specific target-organ toxicity involving the liver. The work reflects the liver’s importance in safety assessment because exposure-related hepatic injury and cytotoxicity are key considerations when classifying chemical hazards. The supplied sentence describes the study objective but does not provide its classification results 42162780May.

• A New England Journal of Medicine study investigated VERVE-102, an experimental base-editing therapy designed to durably inactivate PCSK9 in the liver for treatment of hypercholesterolemia. This approach uses hepatocytes as the target cellular compartment and aims to alter a hepatic genetic pathway involved in circulating lipid regulation. The provided context identifies the therapeutic design but does not state clinical efficacy or safety findings 42187087May.

• Transplantation research examined cradle compression during normothermic machine perfusion (NMP) of liver grafts. The study evaluated the incidence of this compression, associated risk factors, and its impact on postoperative outcomes. It extends the transplantation and clinical-outcomes theme by considering how mechanical conditions during ex vivo perfusion may relate to subsequent graft performance; specific incidence and outcome data were not included in the supplied context 42204402May.

• A national analysis of donation after circulatory death (DCD) liver transplantation investigated livers that were not allocated or procured. The study identified a substantial proportion of DCD donor livers as not proceeding to allocation or procurement, framing organ utilization as a major issue in transplantation practice. The provided context does not quantify the proportion or identify the causes of non-use 42212734May.

• An investigation of insulin resistance after a diet switch and calorie reduction analyzed metabolic remodeling in the liver. Improved hepatic insulin sensitivity was associated with lower triacylglycerol and diacylglycerol levels, reduced protein kinase C epsilon activity, substantially decreased de novo lipogenesis, and increased ketone production. These findings connect hepatic lipid metabolism with systemic insulin resistance and help extend the hepatic metabolism theme toward metabolic adaptation after dietary change 42090498May.

• A sub-study of the POWER randomized clinical trial examined whether reductions in liver and kidney volume after metabolic bariatric surgery could contribute to metabolic adaptation. The authors noted that the liver and kidneys together account for approximately 30% of resting metabolic rate and proposed that changes in the volume of these highly metabolic organs may contribute to a greater-than-expected reduction in resting energy expenditure, potentially promoting weight regain. The supplied context presents this as the study’s proposed relationship and does not provide the measured volume or metabolic results 41875670Mar.